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Frequency and cost of chemotherapy-related serious adverse effects in a population sample of women with breast cancer / Michael J. Hassett, [i 4 més]

Creator: Hassett, Michael J. [autor].

Material type: Article

ArticleDescription: 2006.Content type: text Media type: informàtic Carrier type: recurs en líniaISSN: 00278874.New identifier: NLM16912263Subject(s): Càncer de mama

| Quimioteràpia

| Reaccions adverses

Online resources: Accés lliure

Contents:

Autors: Michael J. Hassett, A. James O'Malley, Juliana R. Pakes, Joseph P. Newhouse, Craig C. Earle

In: JNCI: Journal of the National Cancer Institute 2006 AGO;98(16):1108–1117Summary: Abstract Background: The number, nature, and costs of serious adverse effects experienced by younger women receiving chemotherapy for breast cancer outside of clinical trials are unknown. Methods: From a database of medical claims made by individuals with employer-provided health insurance between January 1998 and December 2002, we identified 12 239 women 63 years of age or younger with newly diagnosed breast cancer, of whom 4075 received chemotherapy during the 12 months after the initial breast cancer diagnosis and 8164 did not. Diagnostic codes for eight chemotherapy-related adverse effects were identified. Total hospitalizations for all causes, hospitalizations or emergency room visits for adverse effects that are typically related to chemotherapy, and health care expenditures were compared between the two groups of women. All statistical tests were two-sided. Results: Women who received chemotherapy were more likely than those who did not to be hospitalized or to visit the emergency room for all causes (61% versus 42%; mean difference = 19%, 95% confidence interval [CI] = 16.7% to 21.3%, P <.001) and for chemotherapy-related serious adverse effects (16% versus 5%, mean difference = 11%, 95% CI = 9.6% to 12.4%, P <.001). The percentages of chemotherapy recipients who were hospitalized or visited the emergency room during the year after their breast cancer diagnosis were 8.4% for fever or infection; 5.5% for neutropenia or thrombocytopenia; 2.5% for dehydration or electrolyte disorders; 2.4% for nausea, emesis, or diarrhea; 2.2% for anemia; 2% for constitutional symptoms; 1.2% for deep venous thrombosis or pulmonary embolus; and 0.9% for malnutrition. Chemotherapy recipients incurred large incremental expenditures for chemotherapy-related serious adverse effects ($1271 per person per year) and ambulatory encounters ($17 617 per person per year). Conclusions: Chemotherapy-related serious adverse effects among younger, commercially insured women with breast cancer may be more common than reported by large clinical trials and lead to more patient suffering and health care expenditures than previously estimated. Topic: chemotherapy regimen, emergency service, hospital, diagnosis, breast cancer

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Holdings
Item type	Current library	Collection	Call number	URL	Status	Date due	Barcode	Course reserves
Journal article	Escola Universitària d'Infermeria i Teràpia Ocupacional de Terrassa Internet	En línia		Text complet	Exclòs de préstec		0010173078966	Recursos d'Ajuda per a les persones de suport (Pla antic) 200440 Grau en Infermeria

20071207

English

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